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赵 萍
西南大学 二级教授，博士生导师
重庆英才·创新创业示范团队负责人
重庆市蚕丝纤维新材料工程技术研究中心副主任
学习工作经历
2022年至今 西部（重庆）科学城种质创制大科学中心 家蚕种质创制团队科研人员
2018至今 西南大学 二级教授
2010至今 西南大学 博士生导师
2007至今 西南大学 教授
2005－2008 西南大学 博士
2002－2007 西南大学 副教授 硕士生导师
2000－2002 日本九州大学农学部 硕士
1997－1999 日本九州大学农学部 访问研究员
1985－1997 四川农科院蚕业研究所 助理研究员
1981－1985 西南农业大学 学士
研究方向及贡献
1、家蚕功能基因组与蛋白质组学研究：参加完成了家蚕全基因组框架图谱和精细图的绘制工作，建立了家蚕蛋白质组学研究技术体系，为实验室家蚕蛋白质组学研究的学术带头人。完成了家蚕各组织器官蛋白组的“全景图”，首次系统解析和报道了蚕丝全蛋白组成，从蚕丝中新发现了400多种蛋白质，纠正了国际上几十年来认为蚕丝只有几种蛋白的传统理解误区，同时还发现蚕丝拥有众多防御功能的生物活性蛋白。
2、蚕丝蛋白功能与创新应用研究：系统探索和研究蚕丝中新基因新蛋白的功能，阐释了蚕丝蛋白的抗菌性能及抗菌机理，揭示了蚕丝蛋白保护功能的分子机理，解开了蚕丝“千年不腐”的秘密， 通过家蚕遗传操作技术和蚕丝结构与性能的研究，获得了适用于纺织服装、生物医学、日化美容等多个领域的高强度多用途新型蚕丝材料和功效产物。开发和推广家蚕省力化、智能化和规模化的养殖技术和蚕丝功能蛋白新产品新材料的成果转化。
科研成果：
主持完成了“863”子课题、国家自然科学基金等20余项科研项目。获国家发明专利20余项。发表重要学术研究论文200余篇，获重庆市自然科学奖二等奖和三等奖各一项。获重庆市精品课程一项。
代表性论文/论著：（* corresponding author）
1.Kaiyu Guoa, Xiaolu Zhanga, Dongchao Zhaoa,Lixia Qina,Wenchao ,Jianga, Wenbo Hua, Xiao Liua, Qingyou Xia, Zhaoming Donga*, Ping Zhao*. Identification and characterization of sericin5 reveals non-cocoon silk sericin components with high β-sheet content and adhesive strength . Acta Biomaterialia 2022，15096–110
2.Xin Wanga, Xiaoqian Xiea, Kang Xiea, Qingsong Liua, Yi Li, Xiaoyin Tana, Haonan Donga, Xinning Li, Zhaoming Dong, Qingyou Xia, Ping Zhao*. Chitin and cuticle proteins form the cuticular layer in the spinning duct of silkworm. Acta Biomaterialia 2022，145：260–271
3.Jingya Heng#，Huawei Liu# , Jiahui Xu, Xuan Huang, Xiaotong Sun, Runze Yang , Qingyou Xia，Ping Zhao*. KPI5 Is Involved in the Regulation of the Expression of Antibacterial Peptide Genes and Hemolymph Melanization in the Silkworm, Bombyx mori. Frontiers in Immunology.2022.5(13)907427
4.Xiaolu Zhang , Yuhui Ni , Kaiyu Guo, Zhaoming Dong , Yuqing Chen , Hongtao Zhu, Qingyou Xia, Ping Zhao.The mutation of SPI51, a protease inhibitor of silkworm, resulted in the change of antifungal activity during domestication. Insect Biochem. Mol. Biol.2021,178 :63–70
5.Huawei Liu, Jingya Heng, Luoling Wang, Youshan Li, Xin Tang, Xuan Huang, Qingyou Xia, Ping Zhao* Homeodomain proteins POU-M2, antennapedia and abdominal-B are involved in regulation of the segment-specific expression of the clip-domain serine protease gene CLIP13 in the silkworm, Bombyx mori. Insect Science 2021,00, 1–17, DOI 10.1111/1744-7917.12916
6.Qiang Sun, Huizhen Guo, Qingyou Xia, Liang Jiang*, Ping Zhao* Transcriptome analysis of the immune response of silkworm at the early stage of Bombyx mori bidensovirus infection. Dev. Comp. Immunol ，2020 ,106: 103601
7.Yan Zhang, Muya Tang, Zhaoming Dong, Dongchao Zhao, Lingna An, Hongtao Zhu, Qingyou Xia, Ping Zhao*. Synthesis, secretion, and antifungal mechanism of a phosphatidylethanolamine-binding protein from the silk gland of the silkworm Bombyx mori. International Journal of Biological Macromolecules. 2020;149:1000-1007.
8.Huawei Liu, Jingya Heng, Luoling Wang, Xin Tang, Pengchao Guo, Youshan Li, Qingyou Xia, Zhao, P* . Identification, characterization, and expression analysis of clip-domain serine protease genes in the silkworm, Bombyx mori. Dev. Comp. Immunol. 2020, 105, 103584
9.W.ang, X., Li, Y., Liu, Q., Tan, X., Xie, X., Xia, Q., & Zhao, P.* GC/MS-based metabolomics analysis reveals active fatty acids biosynthesis in the Filippi's gland of the silkworm, Bombyx mori, during silk spinning. Insect Biochem. Mol. Biol., 2019,105, 1-9.
10.Tang, M., Dong, Z., Guo, P., Zhang, Y., Zhang, X., Guo, K., An, L., Liu, X., Zhao, P.* . Functional analysis and characterization of antimicrobial phosphatidylethanolamine-binding protein BmPEBP in the silkworm Bombyx mori. Insect Biochem. Mol. Biol., 2019,110, 1-9.
11.Guo, P., Wang, Z., Wang, Q., Liu, H., Zhang, Y., Xu, H., & Zhao, P*. Fibroinase and its physiological inhibitors involved in the regulation of silk gland development in the silkworm, Bombyx mori. Insect Biochem. Mol. Biol, 2019,106, 19-27.
12.Wang, L., Liu, H., Fu, H., Zhang, L., Guo, P., Xia, Q., & Zhao, P.* Silkworm serpin32 functions as a negative-regulator in prophenoloxidase activation. Dev. Comp. Immunol, 2019.91, 123-131
13.Qiang Sun, Liang Jiang*, Huizhen Guo, Fei Xia, Bingbing Wang, Yumei Wang, Qingyou Xia, Ping Zhao*. Increased antiviral capacity of transgenic silkworm via knockdown of multiple genes on Bombyx mori bidensovirus. Dev. Comp. Immunol. 2018 (87): 188-192
14.Wang D, Zhang Y, Dong Z, Guo P, Ma S, Guo K, Xia Q, Zhao, P.* . Serine protease P-IIc is responsible for the digestion of yolk proteins at the late stage of silkworm embryogenesis. Insect Biochem. Mol. Biol., 2017,74: 42-49.
15.Wang, X., Li, Y., Liu, Q., Chen, Q., Xia, Q., & Zhao, P*. In vivo effects of metal ions on conformation and mechanical performance of silkworm silks. BBA-General Subjects.2017,1861(3), 567-576.
16.Wang, D., Dong, Z., Zhang, Y., Guo, K., Guo, P., Zhao, P.*, Xia, Q. Proteomics provides insight into the interaction between mulberry and silkworm. Journal of proteome research, 2017,16(7), 2472-2480.
17.Xin Wang, Yi Li, Qingsong Liu, Qingyou Xia, Ping Zhao*. Proteome pro?le of spinneret from the silkworm, Bombyx mori. Proteomics,2017,17(12): 1600301
18.Yi Li, Xin Wang, Yong Hou, Xiaoying, Zhou, Quanmei Chen, Chao Guo, Qingyou Xia, Yan Zhang, Ping Zhao*, Integrative Proteomics and Metabolomics Analysis of Insect Larva Brain: Novel Insights into the Molecular Mechanism of Insect Wandering Behavior, J Proteome Res, 2016, 15(1): 193-204.
19.Xin Wang, Yi Li, Li Peng, Huifang Chen, Qingyou Xia, Ping Zhao*. Comparative transcriptome analysis of Bombyx mori spinnerets and Filippi’s glands suggests their role in silk fiber formation. Insect Biochem. Mol. Biol. 2016, 68: 89-99.
20.Huawei Liu, Youshan Li, Xin Tang, Pengchao Guo, Dandan Wang, Chunyan Zhou, Qingyou Xia, Ping Zhao*. A Midgut- Specific Serine Protease, BmSP36, is Involved in Dietary Protein Digestion in the Silkworm, Bombyx mori. Insect Sci. 2016, Epub ahead of print.
21.Dandan Wang, Yan Zhang, Zhaoming Dong, Pengchao Guo, Sanyuan Ma, Kaiyu Guo, Qingyou Xia, Ping Zhao*. Serine protease P-IIc is responsible for the digestion of yolk proteins at the late stage of silkworm embryogenesis. Insect Biochem. Mol. Biol. 2016, 74: 42-49.
22.Zhaoming Dong, Ping Zhao, Yan Zhang, Qianru Song, Xiaolu Zhang, Pengchao Guo, Dandan Wang, Qingyou Xia*. Analysis of proteome dynamics inside the silk gland lumen of Bombyx mori. Sci Rep.2016, 6: 21158.
23.Xiaomeng Guo#, Zhaoming Dong#, Yan Zhang, Youshan Li, Huawei Liu, Qingyou Xia, Ping Zhao*. Proteins in the Cocoon of Silkworm Inhibit the Growth of Beauveria bassiana. PLoS One, 2016, 11(3):e0151764
24.Zhaoming Dong#, Qianru Song#, Yan Zhang, Shiyi Chen, Xiaolu Zhang, Ping Zhao*, Qingyou Xia. Structure, evolution, and expression of antimicrobial silk proteins, seroins in Lepidoptera, Insect Biochem. Mol. Biol. 2016, 75: 24-31.
25.Zhaoming Dong, Weiwei Zhang, Yan Zhang, Xiaolu Zhang, Ping Zhao*, Qingyou Xia. Identification and Characterization of Novel Chitin-Binding Proteins from the Larval Cuticle of Silkworm, Bombyx mori. J Proteome Res. 2016, 15(5):1435-1445.
26.Yong Hou, Yan Zhang, Jing Gong, Sha Tian, Jianwei Li, Zhaoming Dong, Chao Guo, Li Peng, Ping Zhao*, Qingyou Xia, Comparative proteomics analysis of silkworm hemolymph during the stages of metamorphosis via liquid chromatography and mass spectrometry. Proteomics. 2016 16(9): 1421-1431.
27.Zhaoming Dong, Xiaohuan Wang, Yan Zhang, Liping Zhang, Quanmei Chen, Xiaolu Zhang, Ping Zhao*, Qingyou Xia. Proteome profiling reveals tissue-specific protein expression in male and female accessory glands of the silkworm, Bombyx mori. Amino Acids. 2016 48(5):1173-83.
28.Xin Wang#, Ping Zhao#, Yi Li, Qiying Yi, Sanyuan Ma, Kang Xie, Huifang Chen, Qingyou Xia*. Modifying the mechanical properties of silk fiber by genetically disrupting the ionic environment for silk formation. Biomacromolecules. 2015, 16(10): 3119-3125.
29.Pengchao Guo, Zhaoming Dong, Ping Zhao, Yan Zhang, Huawei He, Xiang Tan, Weiwei Zhang, Qingyou Xia. Structural insights into the unique inhibitory mechanism of the silkworm protease inhibitor serpin18. Sci. Rep. 2015, 5:11863.
30.Yan Zhang#, Ping Zhao#, Zhaoming Dong, Dandan Wang, Xiaomeng Guo, Pengchao Guo, Qianru Song, Weiwei Zhang, Qingyou Xia*, Comparative proteome analysis of multi-layer cocoon of the silkworm, Bombyx mori, PLoS One, 2015, 10(4): e0123403
31.Xin Wang, Yi Li, Kang Xie, Qiying Yi, Quanmei Chen, Xiaohuan Wang, Hong Shen, Qingyou Xia, Ping Zhao*. Ca2+ and endoplasmic reticulum Ca2+-ATPase regulate the formation of silk fibers with favorable mechanical properties. J. Insect Physiol. 2015, 73: 53-59
32.Quanmei Chen, Zhengang Ma, Xin Wang, Zhiqing Li, Yan Zhang, Sanyuan Ma, Ping Zhao*, Qingyou Xia, Comparative proteomic analysis of silkworm fat body after knocking out fibroin heavy chain gene: a novel insight into cross-talk between tissues, Funct Integr Genomics, 2015, 15(5): 611-37
33.Quanmei Chen, Xinyu Liu, Ping Zhao, Yanhui Sun, Xinjie Zhao, Ying Xiong, Guowang Xu, Qingyou Xia. GC/MS-based metabolomic studies reveal key roles of glycine in regulating silk synthesis in silkworm, Bombyx mori. Insect Biochem. Mol. Biol. 2015, 57:41-50.
34.Youshan Li , Ping Zhao, Huawei Liu, Xiaomeng Guo, Huawei He, Rui Zhu, Zhonghuai Xiang, Qingyou Xia, TIL-type protease inhibitors may be used as targeted resistance factors to enhance silkworm defenses against invasive fungi. Insect Biochem. Mol. Biol. 2015, 57:11-19.
35.Pengchao Guo#, Zhaoming Dong, Li Xiao, Tao Li, Yan Zhang, Huawei He, Qingyou Xia, Ping Zhao*, Silk gland-specific proteinase inhibitor serpin16 from the Bombyx mori shows cysteine proteinase inhibitory activity, Biochem. Biophys. Res. Comm. 2015, 457(1): 31–36
36.YouShan Li, Huawei Liu, Rui Zhu, QingYou Xia, Ping Zhao*,. Protease inhibitors in Bombyx mori silk might participate in protecting the pupating larva from microbial infection. Insect Sci. 2015. Epub ahead of print.
37.Xiang Tan, Xiaoming Hu, Xiaowu Zhong, Quanmei Chen, Qingyou Xia, Ping Zhao*,. Antenna-specific Glutathione S-transferase in male silkmoth Bombyx mori. Int. J. Mol. Sci. 2014, 15(5):7429-7443.
38.Yan Zhang, Zhaoming Dong, Peiming Gu, Weiwei Zhang, Dandan Wang, Xiaomeng Guo, Ping Zhao*, Qingyou Xia, Proteomics analysis of adult testis from Bombyx mori, Proteomics, 2014,14: 2345–2349
39.Yan Zhang, Zhaoming Dong, Dandan Wang, Yong Wu, Qianru Song, Peiming Gu, Ping Zhao*, Qingyou Xia, Proteomics of larval hemolymph in Bombyx mori reveals various nutrient-storage and immunity-related proteins, Amino Acids, 2014, 46:1021-1031
40.Xiao-wu Zhong, Xiao-huan Wang, Xiang Tan, Qing-you Xia,Zhong-huai Xiang, Ping Zhao*. Identification and Molecular Characterization of a Chitin Deacetylase from Bombyx mori Peritrophic Membrane. Int. J. Mol. Sci. 2014, 15, 1946-1961.
授权专利：
1. 赵萍，赵东超，张艳，董照明，夏庆友；一种基于家蚕组织样品进行大规模蛋白质组学鉴定的方法。ZL201810479866.3）
2. 赵萍，董照明，郭晓朦，张艳，夏庆友；家蚕蚕茧抗真菌蛋白酶抑制剂在抗真菌中的应用及其制备方法；ZL201510698590.4
3. 赵萍，王鑫，谢康，衣启营，马三垣，夏庆友，家蚕钙离子-ATP酶基因重组表达载体及其应用，ZL2013 1 0516484.0
4. 赵萍，李游山，夏庆友，向仲怀，家蚕蛋白酶抑制剂BmSPI38及其制备方法和应用，ZL2012 1 0063274.6
5. 赵萍，谭祥，夏庆友，胡晓明，陈全梅，家蚕谷胱甘肽-S-转移酶BmGSTD4及其基因，ZL2011 1 0423280.3
6. 夏庆友，孙悦婷，赵萍；具有抗炎丝胶蛋白肽及其应用 ZL202011212340.2
获奖成果：
1、 赵萍，夏庆友，刘春，董照明，郭鹏超；蚕丝蛋白的组成、合成调控及抗菌功能研究，2018年重庆市科学技术奖自然科学奖三等奖。
2、程道军，夏庆友，赵萍，钱文良，林英，家蚕激素的合成调控、信号转导及功能研究，2021年重庆市科学技术奖自然科学奖二等奖。
专著：
赵萍，蚕的基因组（第四章：蚕的基因家族；第五章：家蚕丝氨酸蛋白酶及其抑制剂；第十二章：蚕的蛋白质组）, 科技出版社. 72.3万字，2013
赵萍，蚕体解剖生理学（第十章：丝腺），高等教育出版社，44万字，2015
联系方式
Email：zhaop@swu.edu.cn