何华伟
西南大学 博士、教授、博士研究生导师
生物质产业碳中和技术创新联盟秘书长
国家重要人才计划青年学者
重庆市百名海外高层次人才集聚计划入选者
重庆市蚕丝纤维新材料工程技术研究中心副主任
学习工作经历
2022-至今 西部（重庆）科学城种质创制大科学中心 家蚕种质创制团队科研人员
2012-至今 西南大学 教授
2007-2012 美国西南医学中心 博士后
2002-2007 清华大学 博士
1998-2002 北京林业大学 学士
研究兴趣：
1. 蚕丝蛋白的合成与调控、结构与性能
2. 家蚕生长发育性状调控
3. 蚕丝纤维新材料开发与利用
主要学术兼职：
国家重要人才计划青年学者，重庆市百名海外高层次人才集聚计划入选者，美国化学学会会员、中国生物化学与分子生物学会酶学专业委员会委员、重庆市青年科技领军人才协会会员、重庆市北碚区高层次人才促进会会员、重庆市蚕丝纤维新材料工程技术研究中心副主任、软物质材料化学与功能制造重庆市重点实验室客座研究员、重庆市纳米科技产业技术创新战略联盟-专家委员、生物质产业碳中和技术创新联盟秘书长、国际种业科学家联合体成员，担任智利国家自然科学基金、国家自然科学基金委、教育部、中组部人才计划、国家留学基金委、教育部博士学位论文、国家博士后基金、北京市自然科学基金、浙江省自然科学基金、四川省自然科学基金、重庆市自然科学基金、河北省自然科学基金、广西壮族自治区自然科学基金等项目通讯评审专家，国家重点实验室评审专家，Frontiers in Insect Science，Frontiers in Cell Science，Frontiers in Chemical Biology等期刊客座编辑，Nature Communications，ACS applied materials and interface, FEBS Journal, Insect biochemistry and molecular biology等特邀审稿专家。
科学研究：
解析了Plexin及Plexin-Rap、Plexin-Rac1等蛋白质结构，揭示了Semaphorin-Plexin信号调控神经纤维发育的分子机制。研究了转录因子调控蚕丝基因转录和家蚕丝腺发育的分子机制，通过对蚕丝蛋白结构和性能的研究揭示了家蚕的天然纺丝机制，并以蚕丝蛋白为模板开发了多种蚕丝基生物材料，拓展了蚕丝纤维的应用。近年来，主持和参与国家重点基础研究发展计划(973计划)、国家自然科学基金重点项目、面上项目、青年基金、重庆市自然科学基金创新群体、重点项目、重庆市百人计划专项、中央高校基本科研业务费创新团队项目、重点项目、生物大分子国家重点实验室开放基金、美国国立卫生研究院、美国心脏病协会、美国Welch基金会等多项基金。在Nature Materials、PNAS、eLife、Science signaling等杂志发表60余篇SCI论文，H-index为23，获得国家发明专利授权6项。
成果情况
代表性论文/论著(*，通讯作者；#，同等贡献作者)：
1. Zixuan Huang, Yejing Wang, Min Wu, Wanting Li, Hua Zuo, Bo Xiao, Xueqing Zhang, Jun Wu*, Huawei He*, Qingyou Xia*. Sericin-based gadolinium nanoparticles as synergistically enhancing contrast agents for pH-responsive and tumor targeting magnetic resonance imaging. Materials & Design, 2021, 203:109600.
2. Rui Cai, Gang Tao, Ping Zhao, Qingyou Xia, Huawei He*, Yejing Wang*. POU-M2 promotes juvenile hormone biosynthesis by directly activating the transcription of juvenile hormone synthetic enzyme genes in Bombyx mori. Open Biology, 2022, 12(4):220031.
3. Gang Tao, Rui Cai, Yejing Wang*, Hua Zuo, Huawei He*. Fabrication of antibacterial sericin based hydrogel as an injectable and mouldable wound dressing. Materials Science and Engineering: C, 2021, 119:111597.
4. Wanting Li, Zixuan Huang, Rui Cai, Wan Yang, Huawei He, Yejing Wang*. Rational design of Ag/ZnO hybrid nanoparticles on Sericin/Agarose composite film for enhanced antimicrobial applications. Int J Mol Sciences, 2021, 22:105.
5. Qian Li, Jiemin Zhao, Longfei Liu, Sagun Jonchhe, Felix J Rizzuto, Shankar Mandal, Huawei He, Sansen Wei, Hanadi F Sleiman, Hanbin Mao, Chengde Mao. A poly (thymine)–melamine duplex for the assembly of DNA nanomaterials. Nature Materials, 2020, 19(9):1012-1018.
6. Hai Hou, Huawei He*, Yejing Wang*. Effects of SDS on the activity and conformation of protein tyrosine phosphatase from thermus thermophilus HB27. Scientific Reports, 2020, 10(1): 1-8.
7. Lina Liu, Yejing Wang*, Yu Li, Chaoxiang Ding, Ping Zhao, Qingyou Xia, Huawei He*. Cross-talk between juvenile hormone and ecdysone regulates transcription of fibroin modulator binding protein-1 in Bombyx mori. Int J Biol Macromol, 2019, 128:28-39.
8. Lina Liu, Yejing Wang*, Yu Li, Pengchao Guo, Chun Liu, Zhiqing Li, Feng Wang, Ping Zhao, Qingyou Xia*, Huawei He*. Insights into the repression of fibroin modulator binding protein-1 on the transcription of fibroin H-chain during molting in Bombyx mori. Insect Biochem Mol Biol, 2019, 104:39-49.
9. Xiaoting Hua, Binbin Li, Liang Song, Cuimei Hu, Xianyang Li, Dandan Wang, Ying Xiong, Ping Zhao, Huawei He*, Qingyou Xia*, Fei Wang*. Stimulator of interferon genes (STING) provides insect antiviral immunity by promoting Dredd caspase–mediated NF-κB activation. J Biol Chem, 2018, 293(30):11878-90.
10. Quan Zhang, Tingcai Cheng*, Yueting Sun, Yi Wang, Tieshan Feng, Xiaohong Li, Lihaoyu Liu, Zhiqing Li, Chun Liu, Qingyou Xia*, Huawei He*. Synergism of open chromatin regions involved in regulating genes in Bombyx mori. Insect Biochem Mol Biol, 2019, 110:10-18.
11. Peng Wang, Huawei He*, Rui Cai, Gang Tao, Meirong Yang, Hua Zuo, Ahmad Umar, Yejing Wang*. Cross-linking of dialdehyde carboxymethyl cellulose with silk sericin to reinforce sericin film for potential biomedical application. Carbohydrate Polymers, 2019, 212:403-411.
12. Gang Tao, Rui Cai, Yejing Wang*, Liying Liu, Hua Zuo, Ping Zhao, Ahmad Umar, Chuanbin Mao, Qingyou Xia, Huawei He*. Bioinspired design of AgNPs embedded silk sericin-based sponges for efficiently combating bacteria and promoting wound healing. Materials & Design, 2019, 180:107940.
13. Gang Tao, Yejing Wang*, Rui Cai, Huaipu Chang, Kai Song, Hua Zuo, Ping Zhao, Qingyou Xia, Huawei He*. Design and performance of sericin/poly(vinyl alcohol) hydrogel as a drug delivery carrier for potential wound dressing application. Materials Science and Engineering: C, 2019, 101:341-351.
14. Kai Song, Yu Li, Huawei He*, Lina Liu, Ping Zhao, Qingyou Xia, Yejing Wang. A novel adenosine kinase from Bombyx mori: enzymatic activity, structure and biological function. Int J Mol Sciences, 2019, 20(15):3732.
15. Lisha Ai, Huawei He*, Peng Wang, Rui Cai, Gang Tao, Meirong Yang, Liying Liu, Hua Zuo, Ping Zhao & Yejing Wang*. Rational Design and Fabrication of ZnONPs Functionalized Sericin/PVA Antimicrobial Sponge. Int J Mol Sciences, 2019, 20:4796.
16. Jie Zeng, Wenhao Fu, Zhenping Qi, Qiushuang Zhu, Huawei He, Chengzhi Huang, Hua Zuo, Chengde Mao. Self‐Assembly of Microparticles by Supramolecular Homopoly merization of One Component DNA Molecule. Small, 2019, 15(26):1805552.
17. Huawei He*, Gang Tao, Yejing Wang, Rui Cai, Pengchao Guo, Liqun Chen, Hua Zuo, Ping Zhao, Qingyou Xia. In situ green synthesis and characterization of sericin-silver nanoparticle composite with effective antibacterial activity and good biocompatibility. Materials Science and Engineering: C, 2017, 80:509-516.
18. Huawei He*, Rui Cai, Yejing Wang, Gang Tao, Pengchao Guo, Hua Zuo, Liqun Chen, Xinyu Liu, Ping Zhao, Qingyou Xia. Preparation and characterization of silk sericin/PVA blend film with silver nanoparticles for potential antimicrobial application. Int J Biol Macromol, 2017, 104:457-464.
19. Lina Liu, Yu Li, Yejing Wang, Peng Zhao, Shuguang Wei, Zhenzhen Li, Huaipu Chang, Huawei He*. Biochemical characterization and functional analysis of the POU transcription factor POU-M2 of Bombyx mori. Int J Biol Macromol, 2016, 86: 701-708.
20. Yuxiao Wang#, Huawei He#, Nishi Srivastava, Sheikh Vikarunnessa, Yong-bin Chen, Jin Jiang, Christopher W Cowan, Xuewu Zhang. Plexins Are GTPase Activating Proteins for Rap and Are Activated by Induced Dimerization. Science signaling, 2012, 5(207):ra6.
21. Yuxiao Wang, Heath G Pascoe, Chad A Brautigam, Huawei He, Xuewu Zhang. Structural basis for activation and non-canonical catalysis of the Rap GTPase activating protein domain of plexin. Elife, 2013, 2:e01279.
22. Huawei He, Taehong Yang, Jonathan R Terman, Xuewu Zhang. Crystal structure of the plexin A3 intracellular region reveals an autoinhibited conformation through active site sequestration. PNAS, 2009, 106(37):15610-15615.
联系方式
Email：hehuawei@swu.edu.cn