林  平

西南大学  含弘研究员，博士生导师

巴渝学者（青年学者，2021）

学习与工作简历

2022.01 - 至今 西部（重庆）科学城种质创制大科学中心，家蚕种质创制团队科研人员

2021.09 - 至今 西南大学 含弘研究员

2020.08 - 2021.08 创伤、烧伤与复合伤国家重点实验室 研究员

2016.07 - 2020.09 美国北达科他大学 博士后

2016.02 - 2020.08 创伤、烧伤与复合伤国家重点实验室 助理研究员

2010.09 - 2016.01 西南大学 博士

研究领域

基因编辑工具开发及应用；病原微生物感染与宿主应答；家蚕种质创制。

主要科学贡献

    累计发表文章30余篇，其中以第一作者或通讯作者发表的论文总影响因子超过200；被包括Science述评、Nature review系列、Trends review系列综述，Science、Mol Cell、Nat Chem biol、Adv Sci、Nucleic Acid Res等权威期刊研究论文引400余次。获重庆市科技进步一等奖，重庆市科学技术创新先进个人，任American Association of Immunologists、American Heart Association、中国医促会会员。

     1.围绕CRISPR-Cas系统的调控机制及基因编辑的建立与应用：解析胞内信号通路及关键因子调控CRISPR-Cas系统的分子机制，建立精准、高效的CRISPR-Cas介导的RNA编辑技术体系，用于疾病模型的遗传操作、病原的防治与诊断。相关成果受邀参编著作《CRISPR-Cas Methods: Volume II》相关章节(Springer Nature, 2020)。

     2.基于病原与宿主生物互作机理的研究，发现免疫细胞参与炎症应答的协调机制机理，解析了损伤时细胞自噬作协调DNA修复机制调控宿主的炎症反应，以此参编著作《Oxidative Stress in Lung Diseases》相关章节(Springer Nature, 2019)；

     3.家蚕种质创制方面：绘制了病原菌黑胸败血芽孢杆菌的基因组图谱，鉴定α-toxin、PC等毒素引发家蚕发生败血病的分子机理，开展抗病素材创新 (PLoS Pathogens, 2016)，获2个国家发明专利。

代表性论文（co-first author indicated by #, and corresponding authors indicated by*）

1.Lin P*, Shen G, Guo K*, Qin P, Wang Z, Gao P, Xia Z, Khan N, Jiang J*, Xia Q*, Wu M*. Type III CRISPR-base RNA editing for programmable control of SARS-CoV-2 and human coronaviruses. Nucleic Acids Res. 2022 Feb; gkac016. Doi:10.1093/nar/gkac016.

2.Liu W#, Li L#, Jiang J*, Wu M*, Lin P*. Applications and challenges of CRISPR-Cas gene-editing to disease treatment in clinics. Precis Clin Med. 2021 Sep;4(3):179-191;

3.Lin P, Pu Q, Wu M*. An Approach to Proximity Ligation by T4 RNA Ligase to Screen sRNA That Regulate CRISPR-Cas Systems. In: Islam M, Molla KA, editors. CRISPR-Cas Methods:Volume 2 New York, NY: Springer Nature; 2021. Chapter 19;

4.Pu Q#, Lin P#, Gao P#, et al. Gut Microbiota Regulate Gut-Lung Axis Inflammatory Responses by Mediating ILC2 Compartmental Migration. J Immunol. 2021 Jun 16;

5.Pu Q#, Guo K#, Lin P#, et al. Bitter receptor TAS2R138 facilitates lipid droplet degradation in neutrophils during Pseudomonas aeruginosa infection. Signal Transduct Target Ther. 2021 Jun 4;6(1):210;

6.Lin P, Jiang J*, Wu M*. CRISPR base editor treats premature-aging syndrome. Signal Transduct Target Ther. 2021 Apr 16;6(1):158;

7.Lin P#, Wu Q#, Wu M*. Fossicking for microbial defense system: novel antiviral immunity. Signal Transduct Target Ther. 2020 Nov 27;5(1):281;

8.Lin P,Qin S, Pu Q, et al. Schettler J, Guo K, Li R, Li G, Huang C, Wei Y, Gao GF, Jiang J*, Wu M*. CRISPR-Cas13 Inhibitors Block RNA Editing in Bacteria and Mammalian Cells. Mol Cell. 2020 Jun 4;78(5):850-861.e5;

9.Lin P, Pu Q, Wu Q, et al. High-throughput screen reveals sRNAs regulating crRNA biogenesis by targeting CRISPR leader to repress Rho termination. Nature Communication. 2019 Aug 19;10(1):3728;

10.Lin P#, Pu Q#, Shen G, et al. CdpR Inhibits CRISPR-Cas Adaptive Immunity to Lower Anti-viral Defense while Avoiding Self-Reactivity. iScience. 2019 Mar 29;13:55-68;

11.Lin P,Pu Q, Qin S, et al. DNA Repair Protein OGG1 in Pulmonary Infection and Other Inflammatory Lung Diseases. In: Chakraborti S, Chakraborti T, Das SK, Chattopadhyay D, editors. Oxidative Stress in Lung Diseases Springer Nature Singapore: Springer; 2019. Chapter 4; p.85-8-97;

12.Wang Z#, Pu Q#, Lin P#, Li C*, Jiang J*, Wu M*. Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression. J Vis Exp. 2019 Jun 15;(148).

13.Lin P, Cheng T*, Feng T, et al. Interaction of Bombyx mori aminopeptidase N and cadherin-like protein with Bacillus thuringiensis Cry1Ac toxin. Sheng Wu Gong Cheng Xue Bao. 2018 Nov 25;34(11):1809-1822;

14.Ye Y#, Lin P#, Zhang W, et al. Response to Comment on "DNA Repair Interacts with Autophagy To Regulate Inflammatory Responses to Pulmonary Hyperoxia". J Immunol. 2017 Jul 15;199(2):381-382;

15.Ye Y#, Lin P#, Zhang W, et al. DNA Repair Interacts with Autophagy To Regulate Inflammatory Responses to Pulmonary Hyperoxia. J Immunol. 2017 Apr 1;198(7):2844-2853;

16.Lin P, Cheng T, Ma S, et al. Bacillus bombysepticus α-Toxin Binding to G Protein-Coupled Receptor Kinase 2 Regulates cAMP/PKA Signaling Pathway to Induce Host Death. PLoS Pathog. 2016 Mar;12(3):e1005527;

17.Lin P#, Cheng T#, Jin S, et al. PC, a Novel Oral Insecticidal Toxin from Bacillus bombysepticus Involved in Host Lethality via APN and BtR-175. Sci Rep. 2015 Jun 9;5:11101;

18.Lin P, Cheng T, Jin S, et al. Structural, evolutionary and functional analysis of APN genes in the Lepidoptera Bombyx mori. Gene. 2014 Feb 10;535(2):303-11.

联系方式：

Email: linpingswu@swu.edu.cn；