张晓璐

       西南大学  博士，博士后

      学习工作经历

      2010-2014，山东农业大学，农学学士

      2014-2020，西南大学生物化学与分子生物学，农学博士

      2021至今， 西南大学生物学，博士后

      2022至今，西部（重庆）科学城种质创制大科学中心，家蚕种质创制团队科研人员

      研究领域

      1. 家蚕成丝机理的研究

      2. 家蚕蚕丝蛋白的组学鉴定及功能研究

      3. 基于丝蛋白基因编辑的种质创制和蚕丝素材创制

      成果情况

      代表性论文/论著

      1. Xiaolu Zhang#, Yuhui Ni#, Kaiyu Guo, Zhaoming Dong, Yuqing Chen, Hongtao Zhu, Qingyou Xia, Ping Zhao. Comparing the antifungal activity of BmSPI51 and WildSPI51 reveals the key role of the active site and C-terminal tail [J]. International Journal of Biological Macromolecules，2021,178：63-70.

      2. Xiaolu Zhang#, Kaiyu Guo#, Zhaoming Dong, Zhiyong Chen, Hongtao Zhu, Yan Zhang, Qingyou Xia, Ping Zhao. Kunitz-type protease inhibitor BmSPI51 plays an antifungal role in the silkworm cocoon[J]. Insect Biochem Mol Biol, 2020, 116: 103258.

      3. Xiaolu Zhang, Huaipu Chang, Zhaoming Dong, Yan Zhang, Dongchao Zhao, Lin Ye, Qingyou Xia, and Ping Zhao. Comparative Proteome Analysis Reveals that Cuticular Proteins Analogous to Peritrophin-MotifProteins are Involved in the Regeneration ofChitin Layer in the Silk Gland of Bombyx mori at the Molting Stage[J]. Proteomics, 2018, 18 (19): e1700389.

      4. Hongtao Zhu#, Xiaolu Zhang#, Mengyao Lu, Haiqin Chen, Shiyi Chen, Jiaxuan Han, Yan Zhang, Ping Zhao, Zhaoming Dong. Antibacterial Mechanism of Silkworm Seroins. Polymers.2020,12: 2985-2997.

      5. Kaiyu Guo, Xiaolu Zhang, Zhaoming Dong, Yuhui Ni, Yuqing Chen, Yan Zhang, Haoyun Li, Qingyou Xia, Ping Zhao. Ultrafine and High-Strength Silk Fibers Secreted by Bimolter Silkworms[J]. Plymers, 2020, 12 (11): 1000-1007.

      6. Lei Y, Guo K, Zhang Y, Zhang X, Qin L, Wang X, Zhu H, Guo Y, Yang W, Li B, Xia Q, Zhao P, Dong Z, Adhesive property and mechanism of silkworm egg glue protein, Acta biomaterialia, 2021,134: 499-512.

      7. Zhaoming Dong, Kaiyu Guo, Xiaolu Zhang, Tong Zhang, Yan Zhang, Sanyuan Ma, Huaipu Chang, Muya Tang, Lingna An, Qingyou Xia, Ping Zhao. Identification of Bombyx mori sericin4 protein as a new biological adhesive[J]. International Journal of Biological Macromolecules, 2019, 132: 1121-1130.

      8. Zhaoming Dong, Weiwei Zhang, Yan Zhang, Xiaolu Zhang, Ping Zhao, Qingyou Xia. Identification and characterization of novel chitin-binding proteins from the larval cuticle of silkworm, Bombyx mori[J]. Journal of Proteome Research, 2016, 15 (5): 1435-1445.

      9. Muya Tang, Zhaoming Dong, Pengchao Guo, Yan Zhang, Xiaolu Zhang, Kaiyu Guo, Lingna An, Xinyang Liu, Ping Zhao. Functional analysis and characterization of antimicrobial phosphatidylethanolamine-binding protein BmPEBP in the silkworm Bombyx mori[J]. Insect Biochem Mol Biol, 2019, 110:1-9.

      10. Zhaoming Dong, Ping Zhao, Yan Zhang, Qianru Song, Xiaolu Zhang, Pengchao Guo, Dandan Wang, Qingyou Xia. Analysis of proteome dynamics inside the silk gland lumen of Bombyx mori[J]. Scientific Reports, 2016, 6: 21158-21168.

      11. Zhaoming Dong, Qianru Song, Yan Zhang, Shiyi Chen, Xiaolu Zhang, Ping Zhao, Qingyou Xia. Structure, evolution, and expression of antimicrobial silk proteins, seroins in Lepidoptera[J]. Insect Biochem Mol Biol, 2016, 75: 24-31.

      12. Zhaoming Dong, Xiaohuan Wang, Yan Zhang, Liping Zhang, Quanmei Chen, Xiaolu Zhang, Ping Zhao, Qing you Xia. Proteome profiling reveals tissue-specific protein expression in male and female accessory glands of the silkworm, Bombyx mori[J]. Amino Acids, 2016, 48(5): 1173-83.

      13. Kaiyu Guo, Zhaoming Dong, Yan Zhang, Dandan Wang, Muya Tang, Xiaolu Zhang, Qingyou Xia, Ping Zhao. Improved strength of silk fibers in Bombyx mori trimolters induced by an anti-juvenile hormone compound[J]. Biochimica et Biophysica Acta (BBA) - General Subjects, 2018,1862 (5): 1148-1156.

      14. Zhaoming Dong, Lingna An, Mengyao Lu, Muya Tang, Haiqin Chen, Xuan Huang, Yong Hou, Guanwang Shen, Xiaolu Zhang, Yan Zhang, Qingyou Xia, Ping Zhao. SPINK7 Recognizes Fungi and Initiates Hemocyte-Mediated Immune Defense Against Fungal Infections[J].Frontiers in Immunology，2021,735497.

      15. 张艳，董照明，席星航，张晓璐，叶林，郭凯雨，夏庆友，赵萍. 家蚕脱胶蚕丝的蛋白组成成分[J]. 中国农业科学, 2018,51 (11):2216-2224.

      16. 张薇薇，董照明，张艳，张晓璐，张守亚，赵萍. 家蚕表皮蛋白BmCPAP3-G的表达特征及其与几丁质的结合特性[J]. 中国农业科学, 2017, 50 (9):1723-1733.

      17. 刘华伟，李游山，唐新，张晓璐，赵萍. 家蚕丝氨酸蛋白酶BmSP141的表达特征及对饥饿的响应[J]. 中国农业科学, 2016,49 (6):1207-1218.

      联系方式

       Email：zhangxiaolu@swu.edu.cn