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陆 卫
西南大学 博士，博士后
学习工作经历
2009-2013，四川农业大学动物医学，农学学士
2013-2021，西南大学遗传学，理学博士
2022至今， 西南大学生物学，博士后
2022至今，西部（重庆）科学城种质创制大科学中心，家蚕种质创制团队科研人员
研究领域
1. 基因组编辑
2. 丝蛋白基因改造
成果情况
代表性论文/论著
1. Chang, J.; Chen, X.; Wang, R.; Shi, R.; Wang, X.; Lu, W.; Ma, S.; Xia, Q. High-Throughput Screening Identifies Two Novel Small Molecule Enhancers of Recombinant Protein Expression. Molecules 2020, 25, doi:10.3390/molecules25020353.
2. Hu, W.; Lu, W.; Wei, L.; Zhang, Y.; Xia, Q. Molecular nature of dominant naked pupa mutation reveals novel insights into silk production in Bombyx mori. Insect Biochem. Mol. Biol. 2019, 109, 52–62, doi:10.1016/j.ibmb.2019.04.006.
3. Li, Y.; Ma, S.; Le Sun; Zhang, T.; Chang, J.; Lu, W.; Chen, X.; Liu, Y.; Wang, X.; Shi, R.; et al. Programmable Single and Multiplex Base-Editing in Bombyx mori Using RNA-Guided Cytidine Deaminases. G3 (Bethesda) 2018, 8, 1701–1709, doi:10.1534/g3.118.200134.
4. Liu, Y.; Ma, S.; Wang, X.; Chang, J.; Gao, J.; Shi, R.; Zhang, J.; Lu, W.; Liu, Y.; Zhao, P.; et al. Highly efficient multiplex targeted mutagenesis and genomic structure variation in Bombyx mori cells using CRISPR/Cas9. Insect Biochem. Mol. Biol. 2014, 49, 35–42, doi:10.1016/j.ibmb.2014.03.010.
5. Liu, Y.; Ma, S.; Chang, J.; Zhang, T.; Wang, X.; Shi, R.; Zhang, J.; Lu, W.; Liu, Y.; Xia, Q. Tissue-specific genome editing of laminA/C in the posterior silk glands of Bombyx mori. J. Genet. Genomics 2017, 44, 451–459, doi:10.1016/j.jgg.2017.09.003.
6. Liu, Y.; Liang, Y.; Yang, C.; Shi, R.; Lu, W.; Wang, X.; Wang, R.; Xia, Q.; Ma, S. A deep insight into the transcriptome of midgut and fat body reveals the toxic mechanism of fluoride exposure in silkworm. Chemosphere 2021, 262, 127891, doi:10.1016/j.chemosphere.2020.127891.
7. Lu, W.; Wang, R.; Wang, P.; Ma, S.; Xia, Q. Genetic Code Expansion System for Tight Control of Gene Expression in Bombyx mori Cell Lines. Insects 2021, 12, doi:10.3390/insects12121081.
8. Lu, W.; Lan, X.; Zhang, T.; Sun, H.; Ma, S.; Xia, Q. Precise Characterization of Bombyx mori Fibroin Heavy Chain Gene Using Cpf1-Based Enrichment and Oxford Nanopore Technologies. Insects 2021, 12, doi:10.3390/insects12090832.
9. Ma, S.; Chang, J.; Wang, X.; Liu, Y.; Zhang, J.; Lu, W.; Gao, J.; Shi, R.; Zhao, P.; Xia, Q. CRISPR/Cas9 mediated multiplex genome editing and heritable mutagenesis of BmKu70 in Bombyx mori. Sci Rep 2014, 4, 4489, doi:10.1038/srep04489.
10. Ma, S.; Shi, R.; Wang, X.; Liu, Y.; Chang, J.; Gao, J.; Lu, W.; Zhang, J.; Zhao, P.; Xia, Q. Genome editing of BmFib-H gene provides an empty Bombyx mori silk gland for a highly efficient bioreactor. Scientific Reports 2014, 4, doi:10.1038/srep06867.
11. Ma, S.; Liu, Y.; Liu, Y.; Chang, J.; Zhang, T.; Wang, X.; Shi, R.; Lu, W.; Xia, X.; Zhao, P.; et al. An integrated CRISPR Bombyx mori genome editing system with improved efficiency and expanded target sites. Insect Biochem. Mol. Biol. 2017, 83, 13–20, doi:10.1016/j.ibmb.2017.02.003.
12. Ma, S.; Zhang, J.; Lu, W.; Liu, Y.; Xia, Q. SAA-Cas9: A tunable genome editing system with increased bio-safety and reduced off-target effects. J. Genet. Genomics 2019, 46, 145–148, doi:10.1016/j.jgg.2019.02.004.
13. Ma, S.-Y.; Liu, Y.-Y.; Lu, W.; Wang, X.-G.; Le Sun; Yu, K.; Xia, Q.-Y. Targeted activation of BmCyclinE in Bombyx mori using designer TAL effectors. Insect Sci. 2019, 26, 1055–1058, doi:10.1111/1744-7917.12613.
14. Wang, X.; Ma, S.; Liu, Y.; Lu, W.; Le Sun; Zhao, P.; Xia, Q. Transcriptional repression of endogenous genes in BmE cells using CRISPRi system. Insect Biochem. Mol. Biol. 2019, 111, 103172, doi:10.1016/j.ibmb.2019.05.007.
15. Yan, H.; Liu, Q.; Wen, F.; Bai, B.; Wen, Y.; Chen, W.; Lu, W.; Lin, Y.; Xia, Q.; Wang, G. Characterization and potential application of an α-amylase (BmAmy1) selected during silkworm domestication. Int. J. Biol. Macromol. 2021, 167, 1102–1112, doi:10.1016/j.ijbiomac.2020.11.064.
联系方式
Email：luw@office365.swu.edu.cn