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董照明
西南大学 副研究员，硕士生导师
重庆市“青年拔尖人才”（2021）
学习工作经历
2022~至今 西部（重庆）科学城种质创制大科学中心 家蚕种质创制团队科研人员
2020~至今 西南大学生物学研究中心，副研究员，硕士生导师
2016~2020 西南大学家蚕基因组生物学国家重点实验室，副研究员，硕士生导师
2014~2016 西南大学家蚕基因组生物学国家重点实验室，博士后
2012~2014 西南大学-澳大利亚联邦科工组织，联合培养博士
2008~2014 西南大学家蚕基因组生物学国家重点实验室，博士（硕博连读）
2004~2008 西南大学生物技术学院，学士
获奖及荣誉
2021 重庆英才•青年拔尖人才
2019 重庆市科学技术奖-自然科学奖（蚕丝蛋白的组成、合成调控及抗菌功能研究）
2016 重庆市科协首届自然科学优秀学术论文（比较蛋白质组学揭示了不同发育时期蚕丝蛋白的功能和动态变化）
2015 重庆市优秀博士学位论文（家蚕丝腺中蛋白酶抑制剂的鉴定和功能研究）
学术兼职
2020至今 中国昆虫学会蛾类专业委员会委员
2020至今 重庆劳动教育科学研究会会员
担任Frontiers in Microbiology、Frontiers in Pharmacology、Frontiers Veterinary Science、Scientific Reports、Insects等杂志审稿人
研究领域
1. 蚕丝活性成分的研究与应用。利用蛋白质组学方法鉴定蚕丝中的活性成分；利用分子生物学的方法测定蚕丝成分的多种活性，阐释蚕丝的生物学特征特性；开发和利用蚕丝活性成分，制备个性化、多功能化的蚕丝产品，拓展蚕丝在生物医学材料和化妆品领域的应用。
2. 解析昆虫丝蛋白的起源与进化。通过代表性泌丝动物及其丝蛋白的系统解析，阐明丝蛋白序列结构特征与丝纤维材料理化特性的关系模型；回答丝蛋白起源与进化等基本科学问题；为改造和设计新型丝蛋白材料提供理论支撑。
3. 高性能生物聚合物材料的开发与应用。在解析昆虫丝蛋白各自优越的性能的基础上，合成具有特殊性能的分子模块，利用转基因和基因编辑技术生产特殊性能的蛋白质，并对其结构、力学性能、细胞亲和性等进行表征；评估其应用价值与经济效益。
发明专利：
董照明，赵萍，张艳，雷雨田，夏庆友；一种家蚕卵胶蛋白的截短蛋白及其应用；国家发明专利，专利授权号：ZL202110158004.2
董照明，赵萍，夏庆友，诸鸿韬；Seroin蛋白的截短体及其应用；国家发明专利，专利授权号：ZL202011280285.0
赵萍，董照明，郭晓朦，张艳，夏庆友；家蚕蚕茧抗真菌蛋白酶抑制剂在抗真菌中的应用及其制备方法；国家发明专利，专利授权号：ZL201510698590.4
赵萍，赵东超，张艳，董照明，夏庆友; 一种基于家蚕组织样品进行大规模蛋白质组学鉴定的方法; 国家发明专利，专利授权号：ZL201810479866.3；授权公布号：CN108572214B
代表性论文（近5年）：
2021
1.Yutian Lei, Kaiyu Guo, Yan Zhang, Xiaolu Zhang, Lixia Qin, Xin Wang, Hongtao Zhu, Yuanyuan Guo, Wenxin Yang, Benchi Li, Qingyou Xia, Ping Zhao, Zhaoming Dong*. Adhesive Property and Mechanism of Silkworm Egg Glue Protein. Acta Biomaterialia, 2021. 134: 499-512. (IF=8.947)
2.Zhaoming Dong#, Lingna An#, Mengyao Lu, Muya Tang, Haiqin Chen, Xuan Huang, Yong Hou, Guanwang Shen, Xiaolu Zhang, Yan Zhang, Qingyou Xia, Ping Zhao*. SPINK7 recognizes fungi and initiates hemocyte-mediated immune defence against fungal infections. Frontiers in Immunology, 2021. 12: 735497. (IF=7.561)
3.Zhaoming Dong, Lin Ye, Yan Zhang, Zhiyong Chen, Benchi Li, Tao Zhang, and Ping Zhao. Identification of N-linked Glycoproteins in Silkworm Serum Using Con A Lectin Affinity Chromatography and Mass Spectrometry. Journal of Insect Science, 2021. 21(4): 14. (IF=1.857)
4.Honglei Li#, Lin Wu#, Zhaoming Dong#, Yusong Jiang, Sanjie Jiang, Haitao Xing, Qiang Li, Guocheng Liu, Shuming Tian, Zhangyan Wu, Bin Wu, Zhexin Li, Ping Zhao, Yan Zhang, Jianmin Tang, Jiabao Xu, Ke Huang, Xia Liu, Wenlin Zhang, Qinhong Liao, Yun Ren, Xinzheng Huang, Qingzhi Li, Chengyong Li, Yi Wang, Baskaran Xavier-Ravi, Honghai Li, Yang Liu, Tao Wan, Qinhu Liu, Yong Zou, Jianbo Jian, Qingyou Xia and Yiqing Liu. Haplotype-resolved genome of diploid ginger (Zingiber officinale) and its unique gingerol biosynthetic pathway. Horticulture Research, 2021,8:189. (IF=6.793)
5.Lin Ye, Yan Zhang, Zhaoming Dong, Pengchao Guo, Dongchao Zhao, Haoyun Li, Hang Hu, Xiaofang Zhou, Haiqin Chen, Ping Zhao. Five Silkworm 30K Proteins Are Involved in the Cellular Immunity against Fungi. Insects, 2021. 12(2).107. (IF=2.769)
6.Xiaolu Zhang, Yuhui Ni, Kaiyu Guo, Zhaoming Dong, Yuqing Chen, Hongtao Zhu, Qingyou Xia, Ping Zhao. The mutation of SPI51, a protease inhibitor of silkworm, resulted in the change of antifungal activity during domestication. International Journal of Biological Macromolecules. 2021. 178: 63-70. (IF=6.953)
7.Xin Wang, Xiaoyin Tan, Qingsong Liu, Yi Li, Xinning Li, Zhaoming Dong, Haonan Dong, Qingyou Xia, and Ping Zhao. Fiber Formation and Mechanical Properties of Bombyx mori Silk Are Regulated by Vacuolar-Type ATPase. ACS Biomaterials Science & Engineering, 2021, 7(12): 5532-5540. (IF=4.749)
2020
1.Hongtao Zhu, Xiaolu Zhang, Mengyao Lu, Haiqin Chen, Shiyi Chen, Jiaxuan Han, Yan Zhang, Ping Zhao, Zhaoming Dong*. Antibacterial Mechanism of Silkworm Seroins. Polymers, 2020, 12(12): 2985. (IF=4.329)
2.Yan Zhang, Muya Tang, Zhaoming Dong, Dongchao Zhao, Lingna An, Hongtao Zhu, Qingyou Xia, Ping Zhao. Synthesis, secretion, and antifungal mechanism of a phosphatidylethanolamine-binding protein from the silk gland of the silkworm Bombyx mori. International Journal of Biological Macromolecules, 2020, 149, 1000-1007. (IF=6.953)
3.Xiaolu Zhang, Kaiyu Guo, Zhaoming Dong, Zhiyong Chen, Hongtao Zhu, Yan Zhang, Qingyou Xia, Ping Zhao. Kunitz-type protease inhibitor BmSPI51 plays an antifungal role in the silkworm cocoon. Insect Biochemistry and Molecular Biology, 2019, 103258. (IF=4.714)
4.Kaiyu Guo, Xiaolu Zhang, Zhaoming Dong, Yuhui Ni, Yuqing Chen, Yan Zhang, Haoyun Li, Qingyou Xia, Ping Zhao. Ultrafine and High-Strength Silk Fibers Secreted by Bimolter Silkworms. Polymers, 2020, 12(11): 2537. (IF=4.329)
5.Daoyuan Qin, Genhong Wang, Zhaoming Dong, Qingyou Xia Ping Zhao. Comparative fecal metabolomes of silkworms being fed mulberry leaf and artificial diet. Insects, 2020, 11(12): 851. (IF=2.769)
2019
1.Zhaoming Dong, Kaiyu Guo, Xiaolu Zhang, Tong Zhang, Yan Zhang, Sanyuan Ma, Huaipu Chang, Muya Tang, Lingna An, Qingyou Xia, Ping Zhao. Identification of Bombyx mori sericin 4 protein as a newbiological adhesive. International Journal of Biological Macromolecules. 2019, 132: 1121–1130. (IF=6.953)
2.Muya Tang, Zhaoming Dong, Pengchao Guo, Yan Zhang, Xiaolu Zhang, Kaiyu Guo, Lingna An, Xinyang Liu, Ping Zhao. Functional analysis and characterization of antimicrobial phosphatidylethanolamine-binding protein BmPEBP in the silkworm Bombyx mori. Insect Biochemistry and Molecular Biology. 2019, 110: 1-9. (IF=4.714)
3.Shiyi Chen, Zhaoming Dong, Xiu Ren, Dongchao Zhao, Yan Zhang, Muya Tang, Jiaxuan Han, Lin Ye, Ping Zhao. Proteomic Identification of Immune-Related Silkworm Proteins Involved in the Response to Bacterial Infection. Journal of Insect Science. 2019. 19(4). (IF=1.857)
4.Sirong He, Dan Shi, Zhigang Han, Zhaoming Dong, Yajun Xie, Fengmei Zhang, WenXin Zeng, Qiying Yi. Heparinized silk fibroin hydrogels loading FGF1 promote the wound healing in rats with full-thickness skin excision. Biomed Eng Online, 2019, 18(1), 97. (IF=2.819)
5.Chenchen Lu, Zhiqing Li, Li Chang, Zhaoming Dong, Pengchao Guo, Guanwang Shen, Qingyou Xia, Ping Zhao. Efficient delivery of dsRNA and DNA in cultured silkworm cells for gene function analysis using PAMAM dendrimers system. Insects, 2019, 11(1): 12. (IF=2.769)
6.Zhangchuan Peng, Xi Yang, Chun Liu, Zhaoming Dong, Feng Wang, Xin Wang, Wenbo Hu, Xia Zhang, Ping Zhao, Qingyou Xia. Structural and mechanical properties of silk from different instars of Bombyx mori. Biomacromolecules. 2019, 20(3):1203-1216. (IF=6.988)
7.张艳，董照明，赵东超，李浩云，王凌燕，林英，赵萍. 基于超快速液相-质谱技术对野蚕茧和家蚕茧化学成分进行比较. 生物工程学报, 2019. 35(8): 1546-1556.
2018
1.Kaiyu Guo#, Zhaoming Dong#, Yan Zhang, Dandan Wang, Muya Tang, Xiaolu Zhang, Qingyou Xia, Ping Zhao. Improved strength of silk fibers in Bombyx mori trimolters induced by an anti-juvenile hormone compound. Biochimica et Biophysica Acta (BBA) - General Subjects. 2018, 1862(5): 1148-1156. (IF=3.770)
2.Youshan Li, Zhaoming Dong, Huawei Liu, Rui Zhu, Yu Bai, Qingyou Xia, Ping Zhao. The fungal-resistance factors BmSPI38 and BmSPI39 predominantly exist as tetramers, not monomers, in Bombyx mori. Insect Molecular Biology. 2018, 27(6): 686-697. (IF=3.585)
3.Lingyan Wang, Zhaoming Dong, Juan Wang, Yaru Yin, Huawei Liu, Wenbo Hu, Zhangchuan Peng, Chun Liu, Muwang Li, Yutaka Banno, Toru Shimada, Qingyou Xia, Ping Zhao. Proteomic Analysis of Larval Integument in a Dominant Obese Translucent (Obs) Silkworm Mutant. Journal of Insect Science, 2018, 18(6):1-10. (IF=1.857)
4.Xiaolu Zhang, Huaipu Chang, Zhaoming Dong, Yan Zhang, Dongchao Zhao, Lin Ye, Qingyou Xia, Ping Zhao. Comparative Proteome Analysis Reveals that Cuticular Proteins Analogous to Peritrophin-Motif Proteins are Involved in the Regeneration of Chitin Layer in the Silk Gland of Bombyx mori at the Molting Stage. Proteomics. 2018, e1700389. (IF=3.984)
5.PengChao Guo, Qian Wang, Zhan Wang, Zhaoming Dong, Huawei He, Ping Zhao. Biochemical characterization and functional analysis of invertase Bmsuc1 from silkworm, Bombyx mori. International Journal of Biological Macromolecules, 2018, 107: 2334-2341. (IF=6.953)
6.Huawei Liu, Luoling Wang, Xin Tang, Zhaoming Dong, PengChao Guo, Dongchao Zhao, Qingyou Xia, Ping Zhao. Proteomic analysis of Bombyx mori molting fluid: Insights into the molting process. Journal of proteomics. 2018 (173): 115-125. (IF=4.044)
7.张艳，董照明，席星航，张晓璐，叶林,郭凯雨，夏庆友，赵萍. 家蚕脱胶蚕丝的蛋白组成成分. 中国农业科学. 2018, 51(11): 2216-2224.
联系方式
E-mail：dongzhaoming@swu.edu.cn