王 鑫
西南大学 副教授、硕士生导师
学习工作经历：
2006.9 – 2010.7 成都理工大学 学士
2010.9 – 2012.6 西南大学 硕士
2012.7 – 2016.6 西南大学 博士
2016.7 – 2018.7 西南大学 师资博士后
2018.8 – 2020.9 西南大学 助理研究员
2020.10至今 西南大学 副教授
2022.01至今 西部（重庆）科学城种质创制大科学中心 家蚕种质创制团队科研人员
主要科研领域与方向：
1. 蚕丝纤维成纤机制的研究：利用多组学的手段鉴定家蚕纺丝管道中与蚕丝成纤维相关的因子（金属离子，pH、几丁质、表皮蛋白等），系统性研究成纤维因子在蚕丝性能决定中的作用，阐释蚕丝蛋白成纤维的分子机制以及蚕丝蛋白结构和性能的关系。
2. 高性能新型蚕丝纤维的开发和利用：通过遗传操作手段改变家蚕成纤维因子，以金属离子、表皮蛋白等为靶标，对蚕丝纤维的性能进行定向改良，创制新型高性能蚕丝纤维品种与素材。
科学成就：
从事蚕丝成纤机制及性能改良研究，已发表研究论文28篇，其中以第一作者在Acta Biomaterialia、Biomacromolecules、Insect Biochemistry and Molecular Biology、Biochimica et Biophysica Acta、Proteomics等权威杂志发表论文11篇；获国家发明专利授权3项；主持了国家自然基金青年基金项目、中国博士后科学基金一等资助、重庆市博士后研究项目特别资助项目，并参加了国家973，国家自然科学基金等重大课题的研究。担任Biomacromolecules、International Journal of Biological Macromolecules等SCI期刊的审稿人。
代表性论文/论著：
1.Wang X#, Xie X#, Xie K, Liu Q, Li Y, Tan X, Dong H, Li X, Dong Z, Xia Q, Zhao P*, Chitin and cuticle proteins form the cuticular layer in the spinning duct of silkworm, Acta Biomater, 2022, Online. Link:https://doi.org/10.1016/j.actbio.2022.03.043
2.Wang X#, Zhao P#, Li Y, Yi Q, Ma S, Xie K, Chen H, Xia Q*, Modifying the mechanical properties of silk fiber by genetically disrupting the ionic environment for silk formation, Biomacromolecules, 2015, 16(10): 3119-3125. Link:https://doi.org/10.1021/acs.biomac.5b00724
3.Wang X, Li Y, Liu Q, Tan X, Xie X, Xia Q, Zhao P*, GC/MS-based metabolomics analysis reveals active fatty acids biosynthesis in the Filippi's gland of the silkworm, Bombyx mori, during silk spinning, Insect Biochem Mol Biol, 2019, 105: 1-9. Link:https://doi.org/10.1016/j.ibmb.2018.12.009
4.Wang X, Li Y, Peng L, Chen H, Xia Q, Zhao P*, Comparative transcriptome analysis of Bombyx mori spinnerets and Filippi's glands suggests their role in silk fiber formation, Insect Biochem Mol Biol, 2016, 68: 89-99. Link: https://doi.org/10.1016/j.ibmb.2015.11.003
5.Wang X#, Tan X#, Liu Q, Li Y, Li X, Dong Z, Dong H, Xia Q, Zhao P*, Fiber formation and mechanical properties of Bombyx mori silk are regulated by vacuolar-type ATPase, ACS Biomater Sci Eng, 2021, 7(12): 5532–5540. Link: https://doi.org/10.1021/acsbiomaterials.1c01230
6.Wang X,Li Y, Peng L, Chen H, Xia Q, Zhao P*, In vivo effects of metal ions on conformation and mechanical performance of silkworm silks, Biochim Biophys Acta, 2017, 1861(3): 567-576. Link: https://doi.org/10.1016/j.bbagen.2016.11.025
7.Wang X, Li Y, Liu Q, Xia Q, Zhao P*, Proteome profile of spinneret from the silkworm, Bombyx mori, Proteomics, 2017, 17(12): 1600301. Link: https://doi.org/10.1002/pmic.201600301
8.Wang X, Li Y, Xie K, Yi Q, Chen Q, Wang X, Shen H, Xia Q, Zhao P*, Ca2+ and endoplasmic reticulum Ca2+-ATPase regulate the formation of silk fibers with favorable mechanical properties, J Insect Physiol, 2015, 73: 53-59. Link: https://doi.org/10.1016/j.jinsphys.2015.01.002
9.王鑫, 李懿, 陈全梅, 衣启营, 谢康, 吴用, 赵萍*, 家蚕空泡型ATP酶（V-ATPase）基因的基本信息及表达特征, 中国农业科学, 2014, 47(8): 1611-1621.
10.王鑫, 李懿, 陈慧芳, 周小英, 谢康, 赵萍*, 利用家蚕杆状病毒表达家蚕肌质网型钙离子ATP酶蛋白, 生物工程学报, 2015, 31(3): 421-430.
11.王鑫, 李懿, 刘青松, 李心宁, 夏庆友, 赵萍*, 硝酸钙盐缩处理对生丝结构与力学性能的影响, 西南大学学报（自然科学版）, 接收.
12.Li Y, Wang X, Hou Y, Zhou X, Chen Q, Guo C, Xia Q, Zhang Y, Zhao P*, Integrative proteomics and metabolomics analysis of insect larva brain: Novel insights into the molecular mechanism of insect wandering behavior, J Proteome Res, 2016, 15(1): 193-204.
13.Li Y, Wang X, Chen Q, Hou Y, Xia Q, Zhao P*, Metabolomics Analysis of the Larval Head of the Silkworm, Bombyx mori, Int J Mol Sci, 2016,17(9): 1460.
14.Liu Q, Wang X, Tan X, Xie X, Li Y, Zhao P, Xia Q*, A strategy for improving the mechanical properties of silk fiber by directly injection of ferric ions into silkworm, Mater Des, 2018, 146: 134-141.
15.Liu Q, Wang X, Tan X, Xie X, Dong H, Li X. Li Y, Zhao P, Xia Q*, Disruption of the metal ion environment by EDTA for silk formation affects the mechanical properties of silkworm silk, Int J Mol Sci, 2019, 20: 3026.
16.Tan X, Wang X, Liu Q, Xie X, Li Y, Li B, Li Z, Xia Q, Zhao P*, Inhibition of silkworm vacuolar-type ATPase activity by its inhibitor Bafilomycin A1 induces caspase-dependent apoptosis in an embryonic cell line of silkworm, Arch Insect Biochem Physiol, 2018, 99(3): e21507.
17.Yi Q, Zhao P, Wang X, Zou Y, Zhong X, Wang C, Xiang Z, Xia Q*, Shotgun proteomic analysis of the Bombyx mori anterior silk gland: An insight into the biosynthetic fiber spinning process, Proteomics, 2013, 13(17): 2657-2663.
18.Chen Q, Ma Z, Wang X, Li Z, Zhang Y, Ma S, Zhao P*, Xia Q, Comparative proteomic analysis of silkworm fat body after knocking out fibroin heavy chain gene: a novel insight into cross-talk between tissues, Funct Integr Genomics, 2015, 15(5): 611-637.
19.Tang X, Liu H, Chen Q, Wang X, Xiong Y, Zhao P*, Genome-wide identification, characterization and expression analysis of the solute carrier 6 gene family in silkworm (Bombyx mori), Int J Mol Sci, 2016, 17(10): 1675.
20.Iqbal MI, Sun F, Fei B, Xia Q, Wang X, Hu J*. Knit architecture for water-actuating woolen knitwear and its personalized thermal management, ACS Appl Mater Interfaces, 2021, 13(5): 6298-6308.
21.Shen H, Yan W, Yang X*, He X, Wang X, Zhang Y, Wang B, Xia Q*, Co-occurrence network analyses of rhizosphere soil microbial PLFAs and metabolites over continuous cropping seasons in tobacco, Plant Soil, 2020, 452: 119-135.
22.Peng Z, Yang X, Liu C, Dong Z, Wang F, Wang X, Hu W, Zhang X, Zhao P, Xia Q*, Structural and mechanical properties of silk from different instars of Bombyx mori, Biomacromolecules, 2019, 20(3):1203-1216.
23.Lei Y, Guo K, Zhang Y, Zhang X, Qin L, Wang X, Zhu H, Guo Y, Yang W, Li B, Xia Q, Zhao P*, Dong Z*. Adhesive property and mechanism of silkworm egg glue protein, Acta Biomater. 2021, 134: 499-512.
24.Dong Z, Zhao P, Wang C, Zhang Y, Chen J, Wang X, Lin Y, Xia Q*, Comparative proteomics reveal diverse functions and dynamic changes of Bombyx mori silk proteins spun from different development stages, J Proteome Res, 2013, 12(11): 5213-5222.
25.谢康, 王鑫, 陈慧芳, 李懿, 宋倩茹, 赵萍*, 家蚕前部丝腺特异表皮蛋白Bm11721的鉴定及表达, 生物工程学报, 2016, 32(1): 64-73.
26.陈慧芳, 王鑫, 谢康, 李懿, 赵萍*, 家蚕V型ATP酶B亚基的克隆及表达特征, 生物工程学报, 2016, 32(4): 487-496.
27.陈全梅, 马振刚, 王晓欢, 孙艳慧, 王鑫, 代云香, 赵萍*, 家蚕感受神经膜蛋白基因SNMP1的序列分析及原核表达, 蚕业科学, 2013, 39(2): 231-239.
28.马三垣, 王鑫, 胡文波, 夏庆友, 转基因技术让蚕宝宝吐蜘蛛丝, 人与生物圈, 2018, 6: 50-53.
联系方式：
E-mail：swuwangxin@swu.edu.cn