陶文静

女，博士，教授，硕士研究生导师

主要从事鱼类性别决定与分化、鱼类基因组学等方面研究。承担国家自然科学基金面上项目、青年基金、重庆市自然科学基金、中国博士后自然科学基金等多项项目。在Mol Ecol Resour、Biology of Reproduction、BMC Genomics、Sci China Life Sci、Fish Physiol Biochem和Dev Genes Evol等国外学术杂志发表多篇SCI论文。获重庆市自然科学三等奖1项。入选2019年中国科协优秀中外青年交流计划。从事《生物信息学》、《分子生物学》教学工作。参编《生物信息计算》，参译《系统生物学》。

学习经历

2006/09-2011/12，中国科学院水生生物研究所，博士

2002/09-2006/07，西南大学生命科学学院，学士

研究经历

2022-至今，西南大学生命科学学院，教授

2017-2022，西南大学生命科学学院副研究员，硕士研究生导师

2016-2017，美国马里兰大学，访问学者

2012-2017，西南大学生命科学学院，讲师

目前主持或参加的科研项目

1. 国家自然科学基金面上项目 皮质醇在罗非鱼卵子发生中的功能及作用机制研究主持

2. 重庆市基础研究与前沿探索项目 miRNA 和转录因子在罗非鱼性别决定和分化中的共调节作用研究 主持

3. 中美（NSFC-NSF）生物多样性合作研究项目 性染色体：一个尚未被探究的生物多样性维度主研

4. 国家自然科学基金重点项目 Amhy决定尼罗罗非鱼性别的分子机制研究主研

发表论文

1.Tao W, Xu L*, Zhao L, Zhu Z, Wu X, Min Q, Wang D*, Zhou Q*. 2020. High-quality chromosome-level genomes of two tilapia species reveal their evolution of repeat sequences and sex chromosomes. Mol Ecol Resour. doi: 10.1111/1755-0998.13273.

2. Wu X, Zhao L, Fan Z, Lu B, Chen J, Tan D, Jiang D,Tao W*, Wang D*. 2021. Screening and characterization of sex-linked DNA markers and marker-assisted selection in blue tilapia (Oreochromis aureus). Aquaculture 530, 735934.

3. Zheng Q, Xiao H, Shi H, Wang T, Sun L,Tao W, Kocher TD, Li M, Wang D. Loss of Cyp11c1 causes delayed spermatogenesis due to the absence of 11-ketotestosterone. J Endocrinol. 2020 Mar;244(3):487-499. doi: 10.1530/JOE-19-0438.

4. Zhang SQ, Wang XS, Zhang S, Long J,Tao WJ, Li MH, Wang DS*. 2020. Screening and characterization of sex-linked DNA markers and marker-assisted selection in the Southern catfish (Silurus meridionalis). Aquaculture 517:734783

5.Tao W,Shi H, Yang J, Diakite H, Kocher TD, Wang D. Homozygous mutation of foxh1 arrests oogenesis causing infertility in female Nile tilapia. Biol Reprod. 2020.102(3):758-769. doi: 10.1093/biolre/ioz225.

6.Tao WJ, Yang L, Mayden L. Richard, He SP. Phylogenetic relationships of Cypriniformes and plasticity of pharyngeal teeth in the adaptive radiation of cyprinids. Sci China Life Sci. 2019 Apr;62(4):553-565.

7.Tao WJ, Chen JL , Tan DJ, Yang J, Sun LN, Wei J, Conte MA, Kocher TD, Wang DS. Transcriptome display during tilapia sex determination and differentiation as revealed by RNA-Seq analysis. BMC Genomics, 2018.05.15, 19: 0~363.

8. Zheng S, Long J, Liu Z,Tao W, Wang D*.2018. Identification and evolution of TGF-β signaling pathway members in twenty-four animal species and expression in tilapia. Int J Mol Sci. 2018 Apr 11;19(4). pii: E1154. doi: 10.3390/ijms19041154.

9. Sun S, Cai J,Tao W, Wu L, Tapas C, Zhou L*, Wang D*. 2018. Comparative transcriptome profiling and characterization of gene expression for ovarian differentiation under RU486 treatment. Gen Comp Endocrinol. 2018 May 15;261:166-173. doi: 10.1016/j.ygcen.2018.03.005.

10. 35. Wu TL, Cheng YY, Liu ZL,Tao WJ, Zheng SQ, Wang DS*. 2018. Bioinformatic analyses of zona pellucida genes in vertebrates and their expression in Nile tilapia. Fish Physiology and Biochemistry. 44(2): 435-449.

11. Jiang D, Chen J, Fan Z, Tan D, Zhao J, Shi H, Liu Z,Tao W, Li M, Wang D* 2017. CRISPR/Cas9-induced disruption of wt1a and wt1b reveals their different roles in kidney and gonad development in Nile tilapia. Dev Biol. Aug 1;428(1):63-73. doi: 10.1016/j.ydbio.2017.05.017.

12.Tao WJ, Sun LN, Shi HJ, Cheng YY, Jiang DN, Fu B, Conte MA, Gammerdinger WJ, Kocher TD, Wang DS. 2016. Integrated analysis of miRNA and mRNA expression profiles in tilapia gonads at an early stage of sex differentiation. BMC Genomics. 17:328.

13.Tao WJ, Sun LN, Chen JL, Shi HJ, Wang DS. Genomic identification, rapid evolution, and expression of Argonaute genes in the tilapia,Oreochromis niloticus. Dev Genes Evol, 2016.9, 226(5): 339~348.

14. Chen L, Jiang X, Feng H, Shi H, Sun L,Tao W, Xie Q, Wang D*. 2016. Simultaneous exposure to estrogen and androgen resulted in feminization and endocrine disruption. J Endocrinol. 228(3):205-218.

15. Wei L, Yang C,Tao W, Wang D*. 2016. Genome-wide identification and transcriptome-based expression profiling of the sox gene family in the Nile tilapia (Oreochromis niloticus). Int J Mol Sci. 17(3):270. pii: E270. doi: 10.3390/ijms17030270.

16. Li M, Feng R, Ma H, Dong R, Liu Z, Jiang W,Tao W, Wang D*. 2016. Retinoic acid triggers meiosis initiation via stra8-dependent pathway in Southern catfish,Silurus meridionalis. Gen Comp Endocrinol. 232:191-8. doi: 10.1016/j.ygcen.2016.01.003.

17. Yuan J^#,Tao WJ^#, Cheng YY, Huang BF, Wang DS*. 2014. Genome-wide identification, phylogeny, and gonadal expression of fox genes in Nile tilapia,Oreochromis niloticus. Fish Physiol Biochem. 40:1239-1252. (共同第一作者).

18. Cheng YY,Tao WJ, Chen JL, Sun LN, Zhou LY, Song Q, Wang DS*. 2015 Genome-wide identification, evolution and expression analysis of nuclear receptor superfamily in Nile tilapia, Oreochromis niloticus. Gene. 569(1):141-152.

19. Zhang X, Wang H, Li M, Cheng Y, Jiang D, Sun L,Tao W, Zhou L, Wang Z, and Wang D*. 2014. Isolation of Doublesex- and Mab-3-Related Transcription Factor 6 and Its Involvement in Spermatogenesis in Tilapia. Biol Reprod. 91(6):136-145.

20.Tao WJ, Yuan J, Zhou LY, Sun LN, Sun YL, Yang SJ, Li MH, Zeng S, Huang BF, Wang DS*. 2013. Characterization of gonadal transcriptomes from Nile tilapia (Oreochromis niloticus) reveals differentially expressed genes. PLoS One. 8: e63604.

21. Wei L, Yang C,Tao WJ, Wang DS. Genome-Wide Identification and Transcriptome-Based Expression Profiling of the Sox Gene Family in the Nile Tilapia (Oreochromis niloticus) , International Journal of Molecular Sciences, 2016.3, 17(3): 270. (共同第一作者)

22. Sun LN, Jiang XL, Xie QP, Yuan J, Huang BF,Tao WJ, Zhou LY, Nagahama Y, Wang DS*. 2014. Transdifferentiation of differentiated ovary into functional testis by long term treatment of aromatase inhibitor in Nile tilapia. Endocrinology. 155:1476-1488.

23.Zou M,Guo B,Tao WJ,Arratia G,He SP*. 2012. Integrating multi-origin expression data improves the resolution of deep phylogeny of ray-finned fish (Actinopterygii). Scientific Reports. 2:665.

24.Tao WJ,Mayden RL,He SP^*. 2012. Remarkable Phylogenetic Resolution of the Most Complex Clade of Cyprinidae (Teleostei:Cypriniformes): A Proof of Concept of Homology Assessment and Partitioning Sequence Data Integrated with Mixed Model Bayesian Analyses. Molecular Phylogenetics and Evolution. 66(3). 603-616.

25.Tao WJ,Zou M,Wang X,Gan X,Mayden RL,He SP*. 2010. Phylogenomic Analysis Resolves the Formerly Intractable Adaptive Diversification of the Endemic Clade of East Asian Cyprinidae (Cypriniformes).PLoS One. 5(10): e13508.

联系方式

地址：重庆市北碚区天生路1号西南大学生命科学学院

邮编：400715

E-mail：enderwin@163.com

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