蒋亮
西南大学 教授 博导
国家重要人才计划青年人才
重庆市杰青
重庆市学术技术带头人
主要经历
2003/09 - 2013/06，西南大学，本科（蚕学）、硕博（生物化学与分子生物学）
2013/07 – 2015/06，西南大学，师资博士后
2015/07 – 2018/06，西南大学，助理研究员
2016/12 – 2017/12，英国牛津大学，访问学者
2018/07 – 至今 西南大学，副教授
2022/01-至今 西部（重庆）科学城种质创制大科学中心 家蚕创制团队科研人员
2022-至今 西南大学，研究员
获奖及荣誉
2014 重庆市优秀博士学位论文
2016 入选《2015年度中国博士后科学基金资助者选介》（全国共100名）
2018 重庆市自然科学二等奖（“家蚕分子育种关键技术与素材创新”， R 2/5）
2022 国家重要人才计划青年人才
2024 重庆市杰出青年科学基金
2024 重庆市学术技术带头人
学术兼职
1. Frontiers in Immunology，2019-至今，副主编（Associate Editor）；
2. Frontiers in Insect Science，2021-至今，副主编（Associate Editor）；
3. Viruses，2023-至今，专刊编辑（Special Issue Editor）；
4. Frontiers in Microbiology，2019-至今，编委（Editorial Board Member）；
5. 国家重要人才计划通讯评审专家、会评专家
6. 国家自然基金、多个省份自然基金评审专家
7. 中国昆虫学会，资源昆虫专业委员会，委员（2023-2027）；
8. 资源昆虫产业国家创新联盟，理事会理事（2019-2024）；
9. 长期担任Insect Biochem Mol Biol、Entomol Gen、J Agric Food Chem、Pestic Biochem Phys、Insect Science、Information Sciences、BMC Genomics、BMC evol biol、Int J Biol Macromol、Dev Comp Immunol、J Invertebr Pathol、Mol Genet Genomics、Virus Res、Insects、Gene、J Econ Entomol、Mol Biotechnol等20多个SCI杂志审稿人。
研究方向
1. 昆虫免疫与抗病毒；
2. 基因编辑与生物育种；
3. 昆虫抗逆及耐受机制；
学术贡献
通过解析家蚕免疫机制及病毒逃逸机制，鉴定关键靶标基因，用于转基因和基因编辑创制抗病毒品种素材。建立了家蚕抗病分子育种平台技术和理论体系，制备了高抗病毒的家蚕品系。担任3个SCI杂志的副主编/编委，专著eBook《Novel Insights into Insect Antiviral Immunity》一部。主持重庆市杰青、国家自然科学基金（2项）、重庆市自然科学基金（2项）、重庆市留创计划项目、中国博士后基金特别资助及面上一等资助、重庆市博士后基金等十多项课题，并主研国家重点研发、973、863等多个国家重大课题；制备抗病毒、耐高温的家蚕素材20余个；在Front Immunol、Insect Biochem Mol Biol、Antivir Res、PLoS Pathogens等国际刊物上发表SCI论文40余篇，其中第一/通讯作者30多篇（20余篇为SCI一区或IF>5）；获得国家发明专利授权14项。
科研项目
1.主持重庆市杰出青年科学基金项目“家蚕抗病毒免疫与高抗素材创制”，2024.7-2027.6
2.主持国家自然基金面上项目“模式识别受体BmPGRP2参与BmNPV侵染的分子机制研究”，2022.1-2025.12。
3.主持国家自然基金青年项目“家蚕中肠特异启动子的构建及在抗病毒遗传改良中的应用”，2016.1-2018.12。
4.主持重庆市留创计划项目“基于抑制剂和基因编辑的家蚕抗病毒研究”，2019.12-2021.12。
5.主持重庆市自然基金“家蚕对剧烈环境温度变化的响应机制及耐高温素材的制备”， 2018.7-2021.6。
6.主持重庆市自然基金“家蚕浓核病毒复制机制及抗性素材创新研究”，2016.7-2019.6。
7.主持中国博士后科学基金特别资助项目“家蚕抗病毒机制研究及转基因抗病毒改良”， 2014.07-2015.06。
8.主持中国博士后科学基金面上一等资助项目“家蚕模式识别受体BmPGRP2的克隆、表达和功能研究”，2014.09-2015.06。
9.主持重庆市博士后特别资助项目“家蚕中肠特异启动子的克隆、鉴定及应用”， 2014.09-2015.06。
10.主持中央高校基金“家蚕质型多角体病毒抗性相关基因的功能研究”，2020.1-2021.12。
11.主持中央高校基金“干涉BmCPV病毒基因提高转基因家蚕抗性研究”， 2016.1-2017.12。
12.主持西南大学博士基金“家蚕质型多角体病毒抗性候选基因的筛选及鉴定”， 2016.1-2017.12。
出版专著
1. Liang Jiang, Xiao-Qiang Yu, Luc Swevers. Novel Insights Into Insect Antiviral Immunity. Lausanne: Frontiers Media SA, 2022, doi: 10.3389/978-2-88974-410-7.
发表论文（*代表通讯作者）：
Review
1. Liang Jiang*. Insights into the antiviral pathways of the silkworm Bombyx mori. Front Immunol, 2021, 639092.
2. Liang Jiang*, Marian R. Goldsmith, Qingyou Xia. Advances in the arms race between silkworm and baculovirus. Front Immunol, 2021, 628151.
3. Liang Jiang, Qingyou Xia*. The progress and future of enhancing antiviral capacity by transgenic technology in the silkworm Bombyx mori. Insect Biochem Mol Biol, 2014, (48): 1-7.
Research paper
2022年
1. Liang Jiang*, Xiao-Qiang Yu, Luc Swevers. Editorial: Novel Insights into Insect Antiviral Immunity. Front Immunol, 2022, 740989.
2021年
1. Liang Jiang*, Enyu Xie, Huizhen Guo, Qiang Sun, Haoyu Liuli, Yumei Wang, Qing Li, Qingyou Xia*. Heat shock protein 19.9 (Hsp19.9) from Bombyx mori is involved in host protection against viral infection. Dev Comp Immunol, 2021 (114): 103790.
2020年
1. Liang Jiang*, Yumei Wang, Huizhen Guo, Qiang Sun, Enyu Xie, Haoyu Liuli, Qing Li, Qingyou Xia*. Toxicological evaluation of transgenic silkworms. Toxicology Research. 2020 (9): 846-854.
2. Yumei Wang, Enyu Xie, Huizhen Guo, Qiang Sun, Qingyou Xia*, Liang Jiang*. Overexpression of Bmhsp19.9 protects BmE cells and transgenic silkworm against extreme temperatures. Int J Biol Macromol. 2020 (150): 1141-1146.
3. Yumei Wang, Zili Wang, Huizhen Guo, Jing Huang, Xueying Li, Qiang Sun, Bingbing Wang, Enyu Xie, Liang Jiang*, Qingyou Xia*. Potential of transferring transgenic DNA from silkworm to chicken. Int J Biol Macromol. 2020 (142): 311-319.
4. Enyu Xie, Huizhen Guo, Liang Jiang*, Qingyou Xia*. Identification of the Vo domain of V-ATPase in Bombyx mori silkworm. Int J Biol Macromol. 2020 (163): 386-392.
5. Qiang Sun, Huizhen Guo, Qingyou Xia, Liang Jiang*, Ping Zhao*. Transcriptome analysis of the immune response of silkworm at the early stage of Bombyx mori bidensovirus infection. Dev Comp Immunol, 2020 (106): 103601.
2019年
1. Liang Jiang*, Weiqiang Liu, Huizhen Guo, Yinghui Dang, Tingcai Cheng, Wanying Yang, Qiang Sun, Bingbing Wang, Yumei Wang, Enyu Xie, Qingyou Xia*. Distinct functions of Bombyx mori peptidoglycan recognition protein 2 in immune responses to bacteria and viruses. Front Immunol, 2019, 00776.
2. Huizhen Guo, Qiang Sun, Bingbing Wang, Yumei Wang, Enyu Xie, Qingyou Xia*, Liang Jiang*. Spry is downregulated by multiple viruses to elevate ERK signaling and ensure viral reproduction in silkworm. Dev Comp Immunol, 2019 (98): 1-5.
3. Huizhen Guo, Guowen Xu, Bingbing Wang, Fei Xia, Qiang Sun, Yumei Wang, Enyu Xie, Zhongyan Lu, Liang Jiang*, Qingyou Xia*. Phosphoenolpyruvate carboxykinase is involved in antiviral immunity against Bombyx mori nucleopolyhedrovirus. Dev Comp Immunol, 2019 (92): 193-198.
4. Bingbing Wang, Liang Jiang*, Huizhen Guo, Qiang Sun, Yumei Wang, Enyu Xie, Qingyou Xia*. Screening of PI3K-Akt-targeting Drugs for Silkworm Against Bombyx mori Nucleopolyhedrovirus. Molecules, 2019 (24): 1260.
2018年
1. Liang Jiang, Chunlin Huang, Bingbing Wang, Huizhen Guo, Qiang Sun, Fei Xia, Guowen Xu, Qingyou Xia*. Enhanced heat tolerance in transgenic silkworm via overexpression of Pyrococcus furiosus superoxide reductase. Insect Biochem Mol Biol, 2018 (92): 40-44.
2. Qiang Sun, Liang Jiang*, Huizhen Guo, Fei Xia, Bingbing Wang, Yumei Wang, Qingyou Xia, Ping Zhao*. Increased antiviral capacity of transgenic silkworm via knockdown of multiple genes on Bombyx mori bidensovirus. Dev Comp Immunol, 2018 (87): 188-192.
3. Ping Zhao, Fei Xia, Liang Jiang, Huizhen Guo, Guowen Xu, Qiang Sun, Bingbing Wang, Yumei Wang, Zhongyan Lu, Qingyou Xia*. Enhanced antiviral immunity against Bombyx mori cytoplasmic polyhedrosis virus via overexpression of peptidoglycan recognition protein S2 in transgenic silkworms. Dev Comp Immunol, 2018 (87): 84-89.
4. Huizhen Guo, Chunlin Huang, Liang Jiang*, Tingcai Cheng, Tieshan Feng, Qingyou Xia*. Transcriptome analysis of the response of silkworm to drastic changes in the ambient temperature. Appl Microbiol Biot, 2018 (102): 10161–10170.
2017年
1. Liang Jiang, Zhengwen Peng, Huizhen Guo, Jingchen Sun, Qiang Sun, Fei Xia, Chunlin Huang, Guowen Xu, Qingyou Xia*. Enhancement of antiviral capacity of transgenic silkworms against cytoplasmic polyhedrosis virus via knockdown of multiple viral genes. Dev Comp Immunol, 2017 (77):138-140.
2. Huizhen Guo, Tingcai Cheng, Zhiwei Chen, Liang Jiang, Youbing Guo, et al. Expression map of a complete set of gustatory receptor genes in chemosensory organs of Bombyx mori. Insect Biochem Mol Biol, 2017 (82): 74-82.
3. Dongxu Xing, Qiong Yang, Liang Jiang, Qingrong Li, Yang Xiao, Mingqiang Ye, Qingyou Xia*. RNA-Seq Analyses for Two Silkworm Strains Reveals Insight into Their Susceptibility and Resistance to Beauveria bassiana Infection. Int. J. Mol. Sci., 2017 (18): 234.
2016年
1. Liang Jiang, Zhengwen Peng, Youbing Guo, Tingcai Cheng, Huizhen Guo, Qiang Sun, Chunlin Huang, Ping Zhao, Qingyou Xia*. Transcriptome analysis of interactions between silkworm and cytoplasmic polyhedrosis virus. Scientific Reports, 2016 (6): 24894.
2. Huizhen Guo, Liang Jiang*, Qingyou Xia*. Selection of reference genes for analysis of stress-responsive genes after challenge with viruses and temperature changes in the silkworm Bombyx mori. Mol Genet Genomic. 2016 (291): 999–1004.
3. Ping Lin, Tingcai Cheng, Sanyuan Ma, Junping Gao, Shengkai Jin, Liang Jiang, Qingyou Xia*. Bacillus bombysepticus α-Toxin Binding to G Protein-Coupled Receptor Kinase 2 Regulates cAMP/PKA Signaling Pathway to Induce Host Death. PLoS Pathogens, 2016 (3): e1005527.
2015年
1. Liang Jiang, Chunlin Huang, Qiang Sun, Huizhen Guo, Tingcai Cheng, Zhengwen Peng, Yinghui Dang, Weiqiang Liu, Guowen Xu, Qingyou Xia*. The 5′-UTR intron of the midgut-specific BmAPN4 gene affects the level and location of expression in transgenic silkworms. Insect Biochem Mol Biol, 2015 (63): 1-6.
2. Liang Jiang, Chunlin Huang, Qiang Sun, Huizhen Guo, Zhengwen Peng, Yinghui Dang, Weiqiang Liu, Dongxu Xing, Guowen Xu, Ping Zhao, Qingyou Xia*. Overexpression of host plant urease in transgenic silkworms. Mol Genet Genomics, 2015 (290): 1117–1123.
2014年
1. Liang Jiang, Qiang Sun, Weiqiang Liu, Huizhen Guo, Zhengwen Peng, Yinghui Dang, Chunlin Huang, Ping Zhao, Qingyou Xia*. Postintegration stability of the silkworm piggyBac transposon. Insect Biochem Mol Biol, 2014 (50): 18-23.
2. Shengkai Jin, Tingcai Cheng, Liang Jiang, Ping Lin, Qiong Yang, Yang Xiao, Takahiro Kusakabe, Qingyou Xia*. Identification of a New Sprouty Protein Responsible for the Inhibition of the Bombyx mori Nucleopolyhedrovirus Reproduction. Plos One, 2014, 9(6): e99200.
3. Ping Lin, Tingcai Cheng, Shengkai Jin, Liang Jiang, Chen Wang, Qingyou Xia*. Structural, evolutionary and functional analysis of APN genes in the Lepidoptera Bombyx mori. Gene, 2014, 535(2): 303-311.
2013年以前
1. Liang Jiang, Ping Zhao, Tingcai Cheng, Qiang Sun, Zhengwen Peng, Yinghui Dang, Xiangwei Wu, Genhong Wang, Shengkai Jin, Ping Lin, Qingyou Xia*. A transgenic animal with antiviral properties that might inhibit multiple stages of infection. Antivir Res, 2013 (98): 171-173.
2. Liang Jiang, Ping Zhao, Genhong Wang, Tingcai Cheng, Qiong Yang, Shengkai Jin, Ping Lin, Yang Xiao, Qiang Sun, Qingyou Xia*. Comparison of factors that may affect the inhibitory efficacy of transgenic RNAi targeting of baculoviral genes in silkworm, Bombyx mori. Antivir Res, 2013 (97): 255-263.
3. Liang Jiang, Tingcai Cheng, Yinghui Dang, Zhengwen Peng, Ping Zhao, Shiping Liu, Shengkai Jin, Ping Lin, Qiang Sun, Qingyou Xia*. Identification of a midgut-specific promoter in the silkworm Bombyx mori. Biochem Biophys Res Co, 2013 (433): 542-546.
4. Liang Jiang, Tingcai Cheng, Ping Zhao, Qiong Yang, Genhong Wang, Shengkai Jin, Ping Lin, Yang Xiao, Qingyou Xia*. Resistance to BmNPV via overexpression of an exogenous gene controlled by an inducible promoter and enhancer in transgenic silkworm, Bombyx mori. PLoS One, 2012 (7): e41838.
5. Liang Jiang, Genhong Wang, Tingcai Cheng, Qiong Yang, Shengkai Jin, Gai Lu, Fuquan Wu, Yang Xiao, Hanfu Xu, Qingyou Xia*. Resistance to Bombyx mori nucleopolyhedrovirus via overexpression of an endogenous antiviral gene in transgenic silkworm. Arch Virol, 2012 (157): 1323-1328.
联系方式：
Email：jiangliang@swu.edu.cn；jiangl_swu@163.com