沈关望
九三学社社员，西南大学副研究员，硕士研究生导师
工作经历
2021.07 - 至今 西南大学 前沿交叉学科研究院生物学研究中心 副研究员
2022.01 - 至今 西部（重庆）科学城种质创制大科学中心 家蚕种质创制团队科研人员
研究领域
基因编辑与表达调控技术的研究与运用：鉴定变态期家蚕能量代谢的关键基因和表达调控网络；研究家蚕化蛹变态期间，丝蛹能量流动、物质循环和变态发育之间关系的分子机理。
寡食性昆虫的食物选择和适应机制研究：开发家蚕人工饲料；研究家蚕“桑叶适应”机制，创制“饲料适应性”家蚕种质资源。
真菌与宿主的相互作用关系与应用研究：分析球孢白僵菌与家蚕的相互作用关系；研究其作用产物白僵蚕治疗人类相关疾病的分子机制，解析传统中药功效的现代药理。
社会影响
教育部学位论文评审专家、重庆市自然科学基金评审专家、Molecular Nutrition and Food Research、微生物学通报、动物营养学报等学术期刊审稿人。主持国家自然科学基金项目、国家重点研发计划子课题和省部级项目4项，作为主要完成人参与国家自然科学基金项目和省部级项目10余项。在Trends in Biotechnology、Signal Transduction and Targeted Therapy、Nucleic Acids Research、Pesticide Biochemistry and Physiology、Insect science等学术期刊发表研究论文40余篇。获得了“生产推广型”家蚕人工饲料配方，创制了饲料适应的“高丝”、“高纤维素适应”、“低桑叶粉依赖”和“免烘”等特性的家蚕品种素材，针对性的开发基于饲料的家蚕高密度智能养殖技术体系。中央电视台《走近科学》、《创新进行时》、《我爱发明》栏目，光明日报、新华社、重庆日报和渝西都市报等媒体，跟踪报道了该技术体系在我国乡村振兴和现代农业中的示范作用和应用前景。
代表论文
基因编辑与表达调控技术的研究与应用
1. Lin Wu, Li Zhao, Yuting Feng, Jinxin Wu, Xiaoting Hua, Wei Wang, Yuancheng Wang, Zhiqing Li, Qingyou Xia, Ping Lin and Guanwang Shen*. SGDAcn is a suppressor for silk gland endoreplication and development, Insect Science, 2025,32(3), 1–18.
2. Luyu Hou, Jinxin Wu, Die Liu, Haoran Xu, Hongbo Yao, Yiwen Liang, Qingyou Xia, Ping Lin and Guanwang Shen*. Estrogen-Related Receptor Potential Target Genes in Silkworm (Bombyx mori): Insights into Metabolic Regulation. Insects, 2025, 16, 469.
3. Guan Wang Shen, Die Liu, Hao Ran Xu, et al. Estrogen-related receptor, a molecular target against lepidoptera pests. Pesticide Biochemistry and Physiology, 2024, 202, 105947.
4. Guanwang Shen#, Die Liu#, Haoran Xu., et al. A Study on the Effect of Energy on the Development of Silkworm Embryos Using an Estrogen-Related Receptor. Int. J. Mol. Sci. 2023, 24, 14485.
5. Luoxi Li#, Guanwang Shen#,.et al. CRISPR-Cas-mediated diagnostics. Trends in Biotechnology, 2022: 40, (11).
6. Ping Lin#, Guanwang Shen#, Kai Guo., et al. Type III CRISPR-based RNA editing for programmable control of SARS-CoV-2 and human coronaviruses. Nucleic Acids Research. 2022:1–13.
7. Guanwang Shen#, JinxinWu#, Ying Lin., et al. Estrogen-Related Receptor Influences the Hemolymph Glucose Content by Regulating Midgut Trehalase Gene Expression in the Last Instar Larvae of Bombyx mori. Int. J. Mol. Sci. 2021, 22, 4343.
8. G. Shen, J. Wu, C. Han, H., et al. Oestrogen-related receptor reduces vitellogenin expression by crosstalk with the ecdysone receptor pathway in female silkworm, Bombyx mori. Insect Molecular Biology. 2018: 27(4), 454–463.
昆虫的食物选择与适应机制研究
9. 陈涵，吴金鑫，刘沅林，李志清，夏庆友，林平*，沈关望*。桑叶状态对家蚕人工饲料养蚕成绩的影响，蚕业科学，2024，50（6）：0496－0503。
10. JinxinWu, Yungui Zhang, Han Chen, Qingyou Xia, Ping Zhao, Ying Lin and Guanwang Shen*. The Ability to Digest Cellulose Can Significantly Improve the Growth and Development of Silkworms. Insects, 2024, 15,997.
11. JinxinWu#, Lingyi Li#, Daoyuan Qin, Han Chen, Yuanlin Liu, Guanwang Shen* and Ping Zhao*. Silkworm Hemolymph and Cocoon Metabolomics Reveals Valine Improves Feed Efficiency of Silkworm Artificial Diet. Insects. 2024, 15, 291.
12. Qin LJ, Qi JP, Shen GW., et al. Effects of Microbial Transfer during Food-Gut-Feces Circulation on the Health of Bombyx mori. Microbiology Spectrum, 2022, 10, 6.
13. Zhaoming Dong, Lingna An, Mengyao Lu, Muya Tang, Haiqin Chen, Xuan Huang, Yong Hou, Guanwang Shen., et al. SPINK7 Recognizes Fungi and Initiates Hemocyte-Mediated Immune Defense Against Fungal Infections. Frontiers in Immunology. 2021, 12:735497.
真菌与宿主相互作用关系研究
14. Xueqin Mao, Dongxu Xing, Die Liu, Haoran Xu, Luyu Hou, Ping Lin, Qingyou Xia, Ying Lin*, Guanwang Shen*. Ecdysteroid UDP Glucosyltransferase Expression in Beauveria bassiana Increases Its Pathogenicity against Early Instar Silkworm Larvae. Journal of Fungi. 2023, 9, 987.
15. Guanwang Shen, Jinxin Wu, Yong Wang., et al. The expression of ecdysteroid UDP-glucosyltransferase enhances cocoon shell ratio by reducing ecdysteroid titre in last-instar larvae of silkworm, Bombyx mori. Scientific reports. 2018:8:17710.
16. Dongxu Xing, Guanwang Shen, Qingrong Li., et al. Qiong Quality Formation Mechanism of Stiff Silkworm, Bombyx batryticatus Using UPLC-Q-TOF-MS-Based Metabolomics. Molecules 2019, 24, 3780.
联系方式 Email: gwshen@swu.edu.cn.